Telmisatran EP impurity H is a brominated derivative of the parent antihypertensive drug Telmisatran, featuring a substituted benzyl ester moiety with a 4-bromophenyl ring. The compound retains the core 2,6-dimethyl-4-(1H-tetrazol-5-yl)benzoyl group but incorporates a bromine atom at the para-position of the phenyl ring, replacing the hydrogen involved in the ester linkage. This structural modification arises during synthetic pathways via electrophilic bromination. It serves as a critical HPLC reference standard for quantifying process-related impurities in Telmisatran formulations.
On RequestCC(C)(C)OC(=O)C1=CC=CC=C1C2=CC=C(C=C2)CBr
InChI=1S/C18H19BrO2/c1-18(2,3)21-17(20)16-7-5-4-6-15(16)14-10-8-13(12-19)9-11-14/h4-11H,12H2,1-3H3
YHXCWNQNVMAENQ-UHFFFAOYSA-N