ABC01380WS

Tenofovir alafenamide Impurity 3

Tenofovir alafenamide Impurity 3 is a structurally related synthetic byproduct arising from the alafenamide side-chain coupling in the production of tenofovir alafenamide. It retains the cyclopropyl-methylphosphonate core but lacks the terminal 5’-isobutylamino group, featuring an unmodified 2’-deoxy-5’-O-(4-methylphenyl) phosphonate linkage. This impurity results from incomplete amidation during API synthesis, leaving a free primary amine at the alafenamide terminus. It serves as a critical HPLC reference standard for monitoring process purity in tenofovir alafenamide manufacturing.

On Request
Molecular Formula C21H22N5O4P
Molecular Weight 439.4000
CAS Number 342631-41-8 ✓ Verified
PubChem CID 5482365 ↗
Purity N/A
Product Type API Impurity
Parent Drug Tenofovir
Lead Time On Request
IUPAC Name 9-[(2R)-2-(diphenoxyphosphorylmethoxy)propyl]purin-6-amine

📝 Synonyms

342631-41-8 9-[(2R)-2-(diphenoxyphosphorylmethoxy)propyl]purin-6-amine (R)-Diphenyl (((1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate DIPHENYL (R)-(((1-(6-AMINO-9H-PURIN-9-YL)PROPAN-2-YL)OXY)METHYL)PHOSPHONATE G2GN8Y38TV Phosphonic acid, (((1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy)methyl)-, diphenyl ester [(1R)-2-(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]phosphonic Acid, Diphenyl Ester UNII-G2GN8Y38TV CHEMBL9954 orb1146594

🔬 Chemical Identifiers

C[C@H](CN1C=NC2=C(N=CN=C21)N)OCP(=O)(OC3=CC=CC=C3)OC4=CC=CC=C4
InChI=1S/C21H22N5O4P/c1-16(12-26-14-25-19-20(22)23-13-24-21(19)26)28-15-31(27,29-17-8-4-2-5-9-17)30-18-10-6-3-7-11-18/h2-11,13-14,16H,12,15H2,1H3,(H2,22,23,24)/t16-/m1/s1
XWTDSRIRFPGRAW-MRXNPFEDSA-N

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