ABC01384AQ

Tenofovir diphosphate (Crude)

Tenofovir diphosphate (Crude) is a phosphorylated metabolite of the antiretroviral prodrug tenofovir, featuring a cyclopropylmethyl group linked to a diphosphorylated ribose analog. The structure incorporates two phosphonyl moieties in a 5'-triphosphate configuration, with one terminal phosphate esterified to a hydroxyl group. This compound arises as a synthetic intermediate during the multi-step phosphorylation of tenofovir, reflecting incomplete esterification of the terminal phosphate. Its trivalent phosphorus centers and zwitterionic character contribute to its stability as an API impurity. It serves as an HPLC reference standard for quantifying process-related impurities in tenofovir disoproxil fumarate formulations.

On Request
Molecular Formula C9H16N5O10P3
Molecular Weight 447.1700
CAS Number 166403-66-3 ✓ Verified
PubChem CID 5481180 ↗
Purity N/A
Product Type API Impurity
Parent Drug Tenofovir
Lead Time On Request
IUPAC Name [(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethyl-[hydroxy(phosphonooxy)phosphoryl]oxyphosphinic acid

📝 Synonyms

tenofovir diphosphate 166403-66-3 TL2NJ3X9HC RefChem:187851 PMPApp [2-(6-AMINO-9H-PURIN-9-YL)-1-METHYLETHOXY]METHYL-TRIPHOSPHATE TENOFOVIR-DIPHOSPHATE [(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethyl-[hydroxy(phosphonooxy)phosphoryl]oxyphosphinic acid CHEMBL1236349 TNV

🔬 Chemical Identifiers

C[C@H](CN1C=NC2=C(N=CN=C21)N)OCP(=O)(O)OP(=O)(O)OP(=O)(O)O
InChI=1S/C9H16N5O10P3/c1-6(2-14-4-13-7-8(10)11-3-12-9(7)14)22-5-25(15,16)23-27(20,21)24-26(17,18)19/h3-4,6H,2,5H2,1H3,(H,15,16)(H,20,21)(H2,10,11,12)(H2,17,18,19)/t6-/m1/s1
IACQCQDWSIQSRP-ZCFIWIBFSA-N

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