Tetra acetyl Canagliflozin is a fully acetylated derivative of the antidiabetic agent Canagliflozin, featuring four acetyl groups substituting hydroxyl moieties on its benzene and pyran rings. This impurity retains the core sulfonamide-linked phenylpropanoid scaffold but exhibits enhanced lipophilicity due to acetylation. Structurally, it maintains the (S)-configuration at the chiral center and preserves the key pharmacophoric elements required for SGLT2 binding. It arises as a synthetic byproduct during acetylation processes, serving as an HPLC reference standard for quantifying process-related impurities in Canagliflozin formulations.
