Tetra acetyl Empagliflozin

Tetra acetyl Empagliflozin is a fully acetylated derivative of the antidiabetic agent Empagliflozin, featuring four acetyl groups (COCH3) substituting hydroxyl moieties on the glucose moiety's 3-, 4-, 5-, and 6-positions. This impurity arises via esterification of the parent compound’s tetrahydroxylated core, resulting in a fully acetylated hexose scaffold. The compound retains the core benzene-pyran scaffold of Empagliflozin but exhibits enhanced hydrophobicity due to acetyl substitutions. It serves as a reference standard for HPLC-based quantification of acetylation-related process impurities in Empagliflozin synthesis.