Tolterodine Benzyloxyamine derivative

Tolterodine Benzyloxyamine derivative is a synthetic byproduct arising from the substitution of the piperidine amide group in Tolterodine with a benzyloxyamine moiety. This impurity retains the 5-chloro-2-methoxyphenyl ring and 1,1-dimethylethyl side chain of the parent drug but features an O-aryl ether linkage at the nitrogen site. The benzyloxyamine functional group introduces steric hindrance and altered hydrogen bonding capacity compared to the native amide. This compound serves as an HPLC reference standard for quantifying process-related impurities in Tolterodine active pharmaceutical ingredients.