ABC01029XB

Trt-Olmesartan

Trt-Olmesartan is a tert-butyloxycarbonyl (Trt)-protected derivative of Olmesartan, featuring a benzimidazole core linked to a tetrazole moiety via a methylene bridge. The Trt group is appended to the amino functionality of the parent compound, forming a carbamate linkage. This impurity arises during synthetic deprotection steps, where incomplete removal of the Trt protecting group occurs. Its structural similarity to Olmesartan enables interference in analytical assays, necessitating its quantification as a critical process-related impurity. Used as an HPLC reference standard for impurity profiling in Olmesartan drug substance characterization.

On Request
Molecular Formula C43H40N6O3
Molecular Weight 688.8000
CAS Number 761404-85-7 ✓ Verified
PubChem CID 19036305 ↗
Purity N/A
Product Type API Impurity
Parent Drug Olmesartan
Lead Time On Request
IUPAC Name 5-(2-hydroxypropan-2-yl)-2-propyl-3-[[4-[2-(1-trityltetrazol-5-yl)phenyl]phenyl]methyl]imidazole-4-carboxylic acid

📝 Synonyms

Trityl olMesartan acid 761404-85-7 5-(2-hydroxypropan-2-yl)-2-propyl-3-[[4-[2-(1-trityltetrazol-5-yl)phenyl]phenyl]methyl]imidazole-4-carboxylic acid Olmesartan Impurity 11 SCHEMBL1308518 DTXSID30597610 WBRMIXBFMUWHHX-UHFFFAOYSA-N AKOS030623065 IH57931 4-(1-hydroxy-1-methylethyl)-2-propyl-1-{4-[2-(trityltetrazol-5-yl)phenyl]phenyl}methylimidazole-5-carboxylic acid

🔬 Chemical Identifiers

CCCC1=NC(=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NN=NN4C(C5=CC=CC=C5)(C6=CC=CC=C6)C7=CC=CC=C7)C(=O)O)C(C)(C)O
InChI=1S/C43H40N6O3/c1-4-16-37-44-39(42(2,3)52)38(41(50)51)48(37)29-30-25-27-31(28-26-30)35-23-14-15-24-36(35)40-45-46-47-49(40)43(32-17-8-5-9-18-32,33-19-10-6-11-20-33)34-21-12-7-13-22-34/h5-15,17-28,52H,4,16,29H2,1-3H3,(H,50,51)
WBRMIXBFMUWHHX-UHFFFAOYSA-N

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