Velpatasvir R Isomer (Methoxy Methyl) Boc

Velpatasvir R Isomer (Methoxy Methyl) Boc is the stereochemically defined R-enantiomeric variant of velpatasvir, featuring a methoxymethyl group at the C-4 position of the tetrahydropyridine ring, with a tert-butyloxycarbonyl (Boc) protecting group appended to the pyrazine nitrogen. This compound arises from enantioselective synthesis or resolution processes, diverging from the parent drug's S-isomer configuration. Its structural features include a chiral center at the tetrahydropyridine moiety, a methoxy-substituted methylene bridge, and a Boc-protected amine. This impurity serves as a critical HPLC reference standard for enantiomeric purity assessment in velpatasvir API batches.