Vilazidone PIP amide IMP

Vilazidone PIP amide IMP is an API impurity derived from the synthetic pathway of vilazidone, characterized by a pyridin-3-ylpiperazine (PIP) moiety linked via an amide bond to a substituted dibenzofuran scaffold. The compound retains the core aromatic framework of vilazidone but features an altered amide linkage at the piperazine nitrogen, resulting in a structurally distinct byproduct. This impurity arises during coupling reactions involving PIP intermediates and is distinguished by its N-(pyridin-3-yl)piperazine-1-carboxamide functionality. It serves as a critical HPLC reference standard for quantifying process-related impurities in vilazidone active pharmaceutical ingredient batches.