Vildagliptin (2R)-Isomer

Vildagliptin (2R)-Isomer is the diastereomeric counterpart of the antidiabetic agent vildagliptin, differing in the absolute configuration at the chiral center adjacent to the pyrrolidinone ring. This stereoisomer retains the core structure of the parent drug, featuring a substituted pyrrolidinone fused to a para-substituted phenyl ring, with an amide linkage connecting the two aromatic moieties. The (2R) configuration introduces distinct conformational properties, rendering it a critical impurity in vildagliptin synthesis. It serves as a reference standard for chiral HPLC method validation to quantify enantiomeric purity in active pharmaceutical ingredient batches.