Vildagliptin

Vildagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor featuring a pyrazine core linked to a substituted piperazine and a cyclohexylmethyl group. The molecule incorporates an amide bridge connecting the pyrazine and piperazine moieties, with a methyl group on the piperazine nitrogen. Its cyclohexane ring provides conformational rigidity, enhancing metabolic stability. As the parent drug, it directly corresponds to the active pharmaceutical ingredient. This compound serves as an HPLC reference standard for quantification in pharmaceutical formulations.