Voriconazole N-Oxide

Voriconazole N-Oxide is an oxidation derivative of Voriconazole, featuring an N-oxide moiety on the 1H-1,2,4-triazole ring. This impurity arises via oxidative degradation, introducing an oxygenated functional group at the triazole nitrogen. The compound retains the core difluorophenyl and fluorophenyl substituents of the parent drug, with a modified heterocyclic oxidation state. Structural differences include altered electron density and polarity, affecting chromatographic behavior. It serves as an HPLC reference standard for quantifying N-oxide impurity in Voriconazole formulations.