vortioxetine 1-(2-(2,5-dimethylphenylthio)phenyl) piperazine

This compound is a structural analog of vortioxetine, featuring a piperazine ring linked to a phenylthio moiety substituted with 2,5-dimethylphenyl groups. The sulfur bridge introduces a thioether functionality, while the dimethyl substitution on the aryl ring alters electronic and steric properties compared to the parent drug. The phenyl-piperazine scaffold retains partial pharmacophoric similarity but diverges in metabolic stability and solubility profiles. It serves as a critical HPLC reference standard for quantifying process-related impurities in vortioxetine API synthesis.