vortioxetine (2,6-dimethylphenyl)(2-nitrophenyl) sulfane

Vortioxetine (2,6-dimethylphenyl)(2-nitrophenyl) sulfane is a sulfur-containing impurity derived from the parent drug vortioxetine, characterized by a sulfane (S) bridge connecting a 2,6-dimethylphenyl ring and a 2-nitrophenyl moiety. The structure incorporates electron-donating methyl groups and an electron-withdrawing nitro substituent, creating a conjugated aromatic system with distinct redox properties. This compound arises as a synthetic byproduct during vortioxetine production due to incomplete oxidation of the sulfur center. It serves as an HPLC reference standard for quantifying process-related impurities in vortioxetine formulations.