Isopilocarpine

Isopilocarpine is a synthetic alkaloid analog of Pilocarpine, featuring a 3a,8a-dihydroxy-2-oxo-2,3,3a,4,5,6,7,8-octahydro-1H-quinolin-1-ium core with a substituted methylamino group at position 2. Its stereochemistry and hydroxyl positioning differ from the parent compound, altering its cholinergic activity profile. The molecule exhibits a zwitterionic character due to the quaternary ammonium and adjacent carboxylate functionalities. Structurally, it serves as a key intermediate in the synthesis of Pilocarpine derivatives, enabling stereocontrolled modifications for pharmacokinetic optimization.