ABC00963FL

Mometasone Furoate - Impurity A

Mometasone Furoate - Impurity A is a synthetic byproduct arising from the oxidation of the parent corticosteroid's furan-2-ylcarbonyl moiety, resulting in a chlorinated cyclohexyl substitution at the C25 position. This impurity retains the core 11ฮฒ,17ฮฑ-dihydroxy-17ฮฒ-carboxylic acid ester scaffold but features an altered side chain configuration, leading to reduced glucocorticoid receptor affinity. It serves as a critical HPLC reference standard for quantifying process-related variability in API synthesis.

On Request
Molecular Formula C27H29ClO5
Molecular Weight 469.0000
CAS Number 83880-65-3 โœ“ Verified
PubChem CID 13888750 โ†—
Purity N/A
Product Type API Impurity
Parent Drug Mometasone
Lead Time On Request
IUPAC Name [(8S,10S,13S,14S,16R,17R)-17-(2-chloroacetyl)-10,13,16-trimethyl-3-oxo-7,8,12,14,15,16-hexahydro-6H-cyclopenta[a]phenanthren-17-yl] furan-2-carboxylate

๐Ÿ“ Synonyms

83880-65-3 Mometasone Furoate Impurity A M2A68F897F Mometasone furoate impurity A [EP] 21-chloro-16alpha-methyl-3,20-dioxopregna-1,4,9(11)-trien-17-yl furan-2-carboxylate (16alpha)-21-Chloro-17-((2-furanylcarbonyl)oxy)-16-methylpregna-1,4,9(11)-triene-3,20-dione MOMETASONE FUROATE IMPURITY A [EP IMPURITY] Pregna-1,4,9(11)-triene-3,20-dione, 21-chloro-17-((2-furanylcarbonyl)oxy)-16-methyl-, (16alpha)- (16.ALPHA.)-21-CHLORO-17-((2-FURANYLCARBONYL)OXY)-16-METHYLPREGNA-1,4,9(11)-TRIENE-3,20-DIONE 21-CHLORO-16.ALPHA.-METHYL-3,20-DIOXOPREGNA-1,4,9(11)-TRIEN-17-YL FURAN-2-CARBOXYLATE

๐Ÿ”ฌ Chemical Identifiers

C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4(C3=CC[C@@]2([C@]1(C(=O)CCl)OC(=O)C5=CC=CO5)C)C
InChI=1S/C27H29ClO5/c1-16-13-21-19-7-6-17-14-18(29)8-10-25(17,2)20(19)9-11-26(21,3)27(16,23(30)15-28)33-24(31)22-5-4-12-32-22/h4-5,8-10,12,14,16,19,21H,6-7,11,13,15H2,1-3H3/t16-,19-,21+,25+,26+,27+/m1/s1
GSJLBVBYMSNTPZ-XACSLSAESA-N

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